University of Iowa
Department of Biochemistry
4-403 BSB
Iowa City, IA 52242-1109 USA phone: 877-846-8569
or 319-335-7932
fax: (319) 335-9570
biochem@uiowa.edu

Department of Biochemistry

99:130 Biochemistry and Molecular Biology II

Instructors: John Donelson (course director), 4-403 BSB, 335-7934, john-donelson@uiowa.edu; Kris DeMali, 4-470 BSB, 335-7882, kris-demali@uiowa.edu; Dan Weeks, 4-430 BSB, 335-7918, daniel-weeks@uiowa.edu

Time & Location:
Lecture: Monday, Wednesday, Friday, 10:30-11:20 AM, Watzke Auditorium (Aud. 3), BSB
Discussion: Tuesday, 5:00-7:00 PM, Watzke Auditorium (Aud. 3), BSB

Hrs: 3 s.h.

Description: This course is the second semester of the two-semester comprehensive Biochemistry sequence, 99:120 and 99:130. The course covers metabolism of lipds and nitrogen-containing compounds; regulation and integration of metabolism; information transfer in procaryotes and eucaryotes; recombinant DNA techniques; and chemistry and enzymology of replication, transcription, translation, cell transformation, and regulation of gene expression. Prerequisite: 099:120.

Course Requirements: Three 2-hour examinations.

Syllabus, spring semester, 2008

Text: Lehninger Principles of Biochemistry, David L. Nelson and Michael M. Cox, Worth Publishers, 4th edition, 2005.
Supplemental material will be provided in class.

Lecture and Exam Schedule:
1: Carbohydrate Synthesis in Plants
2: Lipids
3: Fatty Acid Catabolism
4: Lipid Biosynthesis
5: Biological Membranes and Transport
EXAM 1
6: Biosignaling
7: Biosynthesis of Amino Acids, Nucleotides and Related Molecules
8: Hormonal Regulation and Integration of Mammalian Metabolism
9: Genes and Chromosomes
EXAM 2
10: DNA Metabolism
11: RNA Metabolism
12: Protein Metabolism
13: Regulation of Gene Expression
14: DNA-based Information Technologies
EXAM 3 (Final exam)