University of Iowa
Department of Biochemistry
4-403 BSB
Iowa City, IA 52242-1109 USA phone: 877-846-8569
or 319-335-7932
fax: (319) 335-9570
biochem@uiowa.edu

Department of Biochemistry

Recent Publications :: M. Todd Washington

Mason, A., Agrawal, N., Washington, M.T., Lesley, S.A., and Kohen, A., (2006) A lag-phase in the reduction of flavin dependent thymidylate synthase (FDTS) revealed a mechanistic missing link. Chem. Commun. 16:1781-1783.
Carlson, K.D., Johnson, R.E., Prakash, L., Prakash, S., and Washington, M.T. (2006) Human DNA polymerase k forms nonproductive complexes with matched primer termini but not with mismatched primer termini. PNAS 103:15776-15781.
Wolfle, W. T., Washington, M. T., Kool, E. T., Spratt, T. E., Helquist, S. A., Prakash, L. and Prakash, S. (2005) Evidence for a Watson-Crick hydrogen bonding requirement in DNA synthesis by human DNA polymerase Kappa. Mol. Cell. Biol. 25:7137-7143.
Carlson, K.D., and Washington M.T. (2005) Mechanism of efficient and accurate nucleotide incorporation opposite 7,8-Dihydro-8-Oxoguanine by Saccharomyces cerevisiae DNA polymerase h. Mol & Cell. Biol. 25:2169-2176.
Washington, M.T., Minko, I.G., Johnson, R.E., Haracka, L., Harris, T.M., Lloyd, R.S., Prakash, S., and Prakash, L. (2004) Efficient and error-free replication past a minor-groove N2-guanine adduct by the sequential action of yeast Rev1 and DNA polymer zeta. Mol. Cell. Biol 24:6900-6906.
Washington, M.T., Minko, I.G., Johnson, R.E., Wolfe, W.T., Harris, T.M., Lloyd, R.S., Prakash, S., and Prakash, L. (2004) Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa. Mol. Cell Biol. 24:5687-5693.
Washington, M.T., Johnson, R.E., Prakash, L., and Prakash, S. (2004) Human DNA polymerase i utilizes different nucleotide incorporation mechanisms dependent upon the template base. Mol. and Cell. Biol. 24: 936-943.
Minko, I.G., Washington, M.T., Kanuri, M., Prakash, L., Prakash, S., and Lloyd, R.S. (2003) Translesion synthesis past acrolein-derived DNA adduct, g-hydroxypropanodeoxyguanosine, by yeast and human DNA polymerase h. J. Biol. Chem. 278:784-790.
Washington, M.T., Johnson, R.E., Prakash, L. and Prakash, S. (2003) The mechanism of nucleotide incorporation by human DNA polymerase h differs from that of the yeast enzyme. Mol. and Cell. Biol 23:8316-8322.
Washington, M.T., Prakash, L., and Prakash, S. (2003) Mechanism of nucleotide incorporation opposite a thymine-thymine dimer by yeast DNA polymerase h. PNAS 100:12093-12098.
Wolfe, W.T., Washington, M.T., Prakash, L., and Prakash, S. (2003) Human DNA polymerase κ uses template-primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions. Genes & Develop. 17:2191-2199.
Washington, M.T., Wolfe, W.T., Spratt, T.E., Prakash, L., and Prakash, S. (2003) Yeast DNA polymerase h makes functional contacts with the DNA minor groove only at the incoming nucleoside trisphosphate. PNAS 100:5113-5118.
Washington, M.T., Helquist, S.A., Kool, E.R., Prakash, L., and Prakash, S. (2003) Requirement of Watson-Crick hydrogen bonding for DNA synthesis by yeast polymerase h. Mol. and Cell. Biol. 23: 5107-5112.
Washington, M. T., Johnson, R. E., Prakash, S. and Prakash L. (2002) Human DINB1-Encoded DNA Polymerase Kappa is a Promiscuous Extender of Mispaired Primer Termini. Proc. Natl. Acad. Sci U.S.A. 99:1910-1914.
Washington, M. T., Prakash, L. and Prakash, S. (2001) Yeast DNA Polymerase Eta Utilizes an Induced-Fit Mechanism of Nucleotide Incorporation. Cell 107:917-927.

Also see PubMed for recent publications.