University of Iowa
Department of Biochemistry
4-403 BSB
Iowa City, IA 52242-1109 USA phone: 877-846-8569
or 319-335-7932
fax: (319) 335-9570
biochem@uiowa.edu

Department of Biochemistry

Recent Publications :: Arthur Spector

Spector, A.A., and Haynes, W.G. (2007) LDL cholesteryl oleate: a biomarker for atherosclerosis? Arterioscler. Thromb. Vasc. Biol. 27:1228-1230.
Fang, X., Dillon, J.S., Hu, S., Harmon, S.D., Yao, J., Anjaiah, S., Falck, J.R., and Spector, A.A. (2007) 20-Carboxy-arachidonic acid is a dual activator of peroxisome prolifrator-activated receptors a and g. Prostaglandins & other Lipid Mediators 82:175-184.
Spector, A.A., and Norris, A.W. (2007) Action of epoxyeicosatrienoic acids on cellular function. Am. J. Physiol. Cell. Physiol. 292:C996-C1012. (Invited review)
Zhou, W., Lu, T., Spector, A.A., and Lee, H.-C. (2006) Inhibition of PGI2 signaling by miconazole in vascular smooth muscle cells. Prostaglandins and other Lipid Mediators 80:28-34. Harmon, S.D., Fang, X., Kaduce, T.L., Hu, S., Raj Gopal, V., Falck, J.R., and Spector, A.. (2006) Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: Effect on 20-hydroxyeicosatetraenoic acid production. Prostaglandins Leukot. Essent. Fatty Acids 75:169-177.
Fang, X., Faraci, F.M., Kaduce, T.L., Harmon, S., Modrick, M., Hu, S., Moore, S., Falck, J., Weintraub, N.L., and Spector, A.A. (2006) 20-Hydroxyeicosatetraenoic acid (20-HETE) is a potent dilator of mouse basilar artery: Role of cyclooxygenase. Am. J. Physiol. Heart Circ. Physiol. 291:H2301-H2307.
Spector, A.A. (2006) HIV protease inhibitors and hyperlipidemia: A fatty acid connection. Arterioscler. Thromb. Vasc. Biol. 26:7-9.
Fang, X., Hu, S., Xu, B., Snyder, G.D., Harmon, S., Yao, J., Liu, Y., Sangras, B., Falck, J.R., Weintraub, N.L., and Spector, A.A. (2006) 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferators-activated receptor-a. Am. J. Physiol. Heart Circ. Physiol. 290:H55-H63.
Liu, Y., Zhang, Y., Schmelzer, K., Lee, T.-S., Fang, X., Zhu, Y., Spector, A.A., Gill, S., Morisseau, C., Hammock, B.D., and Shyy, J. Y.-J. (2005) The antiinflammatory effect of laminar flow: The role of PPARg, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. PNAS 102:16747-16752.
Collins, X.H., Harmon, S.D., Kaduce, T.L., Berst, K.B., Fang, X., Moore, S.A., Raju, T.V., Falck, J.R., Weintraub, N.L., Duester, G., Plapp, B.V., and Spector, A.A. (2005) w-Oxidation of 20-hydroxyeicosatetraenoic Acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4. J. Biol. Chem. 280:33157-33164.
Zhou, W., Wang, X.-L., Kaduce, T.L., Spector, A.A., and Lee, H.-C. (2005) Impaired arachidonic acid-mediated dilation of small mesenteric arteries in Zucker diabetic fatty rats. Am. J. Physiol. Heart. Circ. Physiol. 288:H2210-H2218.
Lu, T., Wang, X.-L., He, T., Zhou, W., Kaduce, T.L., Katusic, Z.S., Spector, A.A., and Lee, H-C. (2005) Impaired arachidonic acid-mediated activation of large-conductance Ca2+-activated K+ channels in coronary arterial smooth muscle cells in Zucker diabetic fatty rats. Diabetes 54:2155-2163.
Fang, X., Hu, S., Watanabe, T., Weintraub, N.L., Snyder, G.D., Yao, J., Lu, Y., Shyy, J. Y.-J., Hammock, B.D., and Spector, A.A. (2005) Activation of peroxisome proliferator-activated receptor a by substituted urea-derived soluble epoxide hydrolase inhibitors. J. of Pharmacology and Experimental Therapeutics 314:260-270.
Chen, P., Hu, S., Yao, J., Moore, S.A., Spector, A.A., and Fang, X. (2005) Induction of cyclooxygenase-2 by anandamide in cerebral microvascular endothelium. Microvascular Research 69:28-35.
Fang, X., Weintraub, N.L., McCaw, R.B., Hu, S., Harmon, S.D., Rice, J.B., Hammock, B.D., and Spector, A. (2004) Effect of soluble epoxide hydrolase inhibition on eposyeicosatrienoic acid metabolism in human blood vessels. Am. J. Physiol. Heart Circ. Physio. 287:H2412-H2420.
Chen, P., Hu, S., Harmon, S.D., Moore, S.A., Spector, A.A. and Fang, X. (2004) Metabolism of anandamide in cerebral microvascular endothelial cells. Prostaglandins Other Lipid Mediat. 73:59-72.
Kaduce, T.L., Fang, X., Harmon, S.D., Oltman, C.L., Dellsperger, K.C., Teesch, L.M., Gopal, V.R., Falck, J.R., Campbell, W.B., Weintraub, N.L., and Spector, A.A. (2004) 20-Hydroxyeicosatetraenoic acid (20-HETE) metabolism in coronary endothelial cells. J. Biol. Chem. 279:2648-2656.
Spector, A.A., Fang, X., Snyder, G.D., Weintraub, N.L. (2004) Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function. Progress in Lipid Res. 43:55-90.
Nwankwo, J.O., Spector, A.A., and Domann, F.E. (2003) A nucleotide insertion in the transcriptional regulatory region of FADS2 gives rise to human fatty acid delta-6-desaturase deficiency. J. Lipid Res. 44:2311-2319.
Oltman, C.L., Kane, N.L., Miller, Jr., F.J., Spector, A.A., Weintraub, N.L., and Dellsperger, K.C. (2003) Reactive oxygen species mediate arachidonic acid-induced dilation in porcine coronary microvessels. Am. J. Physiol. Heart Circ. Physiol. 285:H2309-H2315.
Widstrom, R.L., Norris, A.W., Van der Veer, J., and Spector, A.A. (2003) Fatty acid-binding proteins inhibit hydration of epoxyeicosatrienoic acids by soluble epoxide hydrolase. Biochemistry 42:11762-11767.
Fang, X., Weintraub, N.L., and Spector, A.A. (2003) Differences in positional esterification of 14,15-epoxyeicosatrienoic acid in phosphatidylcholine of porcine coronary artery endothelial and smooth muscle cells. Prostaglandins Other Lipid Mediat. 71:33-42.
Spector, A.A., (2003) Plaque rapture, lysophosphatidic acid, and thrombosis. Circulation 108:641-643.
Li, W.-G., Stoll, L.L., Rice, J.B., Xu, S.-P., Miller, Jr., F.J., Chatterjee, P., Hu, L., Oberley, L.W., Spector, A.A., and Weintraub, N.L., (2003) Activation of NAD(P)H oxidase by lipid hydroperoxides: Mechanism of oxidant-mediated smooth muscle cytotoxicity. Free Radical Biol. & Med. 34(7):937-946.
Harmon, S.D., Kaduce, T.L., Manuel, T.D., Spector, A.A. (2003) Effect of the D6- desaturase inhibitor SC-26196 on polysaturated fatty acid metabolism in human cells. Lipids 38:469-476.
Fang, X., Weintraub, N.L., Oltman, C.L., Stoll, L.L., Kaduce, T.L., Harmon, S., Dellsperger, K.C., Morisseau, C., Hammock, B.D., and Spector, A.A. (2002) Human coronary endothelial cells convert 14, 15-EET to a biologically active chain-shortened epoxide. Am. J. Physiol. Heart Circ. Physiol. 283:H2306-H2314.
Williard, D.E., Harmon, S.D., Kaduce, T.L., Spector, A.A. (2002) Comparison of 20-, and 24-carbon n-3 and n-6 polyunsaturated fatty acid utilization in differentiated rat brain astrocytes. Prostaglandins, Leukotrienes and Essential Fatty Acids 67: 99-104.
Snyder, G.D., Krishna, U.M., Falck, J.R., and Spector, A.A. (2002) Evidence for a membrane site of action for 14,15-EET on expression of aromatase in vascular smooth muscle. Am. J. Physiol. Heart Circ. Physiol. 283: H1936-H1942.
Norris, A.W., and Spector, A.A. (2002) Very long chain n-3 and n-6 polyunsaturated fatty acids bind strongly to liver fatty acid-binding protein. J. Lipid Res. 43: 646-653.
Lu, T., Hoshi, T., Weintraub, N.L., Spector, A.A., and Lee, H.-C. (2001) Activation of ATP-sensitive K+ channels by epoxyeicosatrienoic acids in rat cardiac ventricular myocytes. J. Physiol. 537: 811-827.
Ferdinandusse, S., Denis, S., Mooijer, P.A.W., Zhang, Z., Reddy, J.K., Spector, A.A. and Wanders, R.J.A. (2001) Identification of the peroxisomal ß-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid. J. Lipid Res. 42: 1987-1995.
Williard, D.E., Harmon, S.D., Kaduce, T.L., Preuss, M., Moore, S.A., Robbins, M.E.C., and Spector, A.A. (2001) Docosahexaenoic acid synthesis from n-3 polyunsaturated fatty acids in differentiated rat brain astrocytes. J. Lipid Res. 42: 1368-1376
Spector, A.A. (2001) Plasma free fatty acid and lipoproteins as sources of polyunsaturated fatty acid for the brain. J. Mol. Neurosci. 16: 159-165.
Rapoport, S.I., Chang, M.C.J., and Spector, A.A. (2001) Delivery and turnover of plasma-derived essential PUFAs in mammalian brain. J. Lipid Res. 42: 678-685.
Fang, X., Kaduce, T.L., Weintraub, N.L., Harmon, S., Teesch, L.M., Morrisseau, C., Thompson, D.A., Hammock, B.D., and Spector, A.A. (2001) Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells: Implications for the vascular effects of soluble epoxide hydrolase inhibition. J. Biol. Chem. 276: 14867-14874.
Lu, T., Katakam, P.V.G., VanRollins, M., Weintraub, N.L., Spector, A.A., and Lee, H.-C. (2001) Dihydroxyeicosatrienoic acids are potent activators of Ca2+-activated K+ channels in isolated coronary arterial myocytes. J. Physiol. 534.3: 651-667.
Williard, D.E., Nwankwo, J.O., Kaduce, T.L., Harmon, S.D., Irons, M., Moser, H.W., Raymond, G.V., and Spector, A.A. (2001) Identification of a fatty acid D6-desaturase deficiency in human skin fibroblasts. J. Lipid Res. 42: 501-508.
Widstrom, R.L., Norris, A.W., Spector, A.A. (2001) Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein. Biochemistry 40: 1070-1076.
Zink, M.H., Oltman, C., Lu, T., Katakam, P.V.G., Kaduce, T.L., Lee, H.-C., Dellsperger, K.C., Spector, A.A., Myers, P.R., Weintraub, N.L. (2001) 12-Lipoxygenase in the porcine coronary microcirculation: Implications for coronary vasoregulation. Am. J. Physiol. 280: H693-H704.
Willard, D.E., Harmon, S.D., Preuss, M.A., Kaduce, T.L., Moore, S.A., and Spector, A.A. (2001) Production and release of docosahexaenoic acid by differentiated rat brain astrocytes. World Rev. Nutr. Diet. 88: 168-172.

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