University of Iowa
Department of Biochemistry
4-403 BSB
Iowa City, IA 52242-1109 USA phone: 877-846-8569
or 319-335-7932
fax: (319) 335-9570
biochem@uiowa.edu

Department of Biochemistry

Recent Publications :: Madeline Shea

Erickson, J.R., Joiner, M.L., Guan X., Kutschke, W., Wang, J., Oddis, C.V., Bartlett, R.K., Lowe, J.S., O'Donnell, S., Aykin-Burns, N., Zimmerman, M.C., Zimmerman, K., Ham, A.L., Weiss, R.M., Spitz, D.R., Shea, M.A., Colbran, R.J., Mohler, P.J., Anderson, M. (2008) Direct Oxidation Results in Ca²⁺ Independent Activation of CaMKII Cell (accepted, January 28).
Theoharis, N.T., Sorensen, B.R., Shea, M.A. (2008) Neuronal Voltage–Dependent Sodium Channel Type II (NaV1.2) IQ Motif Lowers Calcium Affinity of the C–domain of Calmodulin Biochemistry 47: 112-123 (http://dx.doi.org/10.1021/bi7013129) (12 pp)
Newman, R.A., VanScyoc, W.S., Jaren, O.R., and Shea, M.A. (2007) Domain-Specific Interactions of Calmodulin with Melittin: Peptide Docks with the C-domain of Apo CaM but Preferentially Increases Calcium Binding Affinity of the N-domain. (in press, Proteins: Structure, Function, Bioinformatics). (http://dx.doi.org/10.1002/prot.21861) (21 pp)
Akyol, Z., Gakhar, L., Sorensen, B.R., Hell, J.W., and Shea, M.A. (2007) The NMDA Receptor NR1 C1 Region Bound to Calmodulin: Structural Insights into Functional Differences between Homologous Domains. (PDB entry: 2HQW) Structure 15: 1603-1617 (http://dx.doi.org/10.1016/j.str.2007.10.012) (15 pp)
Li, Q., Cooper, J.J., Altwerger, G.H., Feldkamp, M.D., Shea, M.A., and Price, D.P. (2007) HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells. Nucleic Acids Research 35: 2503–2512. (http://dx.doi.org/10.1093/nar/gkm150) (10 pp)
Merrill, M.A., Malik, Z., Akyol, Z., Bartos, J.A., Leonard, A.S., Hudmon, A., Shea, M.A. and Hell, J.W. (2007) Displacement of a-Actinin from the NMDA Receptor NR1 C0 Domain by Ca2+/Calmodulin Promotes CaMKII Binding. Biochemistry 46:8485-97 (http://dx.doi.org/10.1021/bi0623025) (13 pp)
VanScyoc, W.S., Newman, R.A., Sorensen, B.R., Shea, M.A. (2006) Calcium Binding to Paramecium Calmodulin Mutants Having Domain–Specific Effects on Regulation of Ion Channels. Biochemistry 45: 14311-14324 (http://dx.doi.org/10.1021/bi061134d) (14 pp)
Ross JBA, Laws W, Shea M. (2006) Intrinsic Fluorescence in Protein Structure Analysis. in Protein Structures: Methods in Protein Structure and Structure Analysis: Luinescence Spectroscopy and Circular Dichroism, Eds. VN Uversky, EA Permyakov, Nova Science Publishers, Inc., New York. 55-72 ISBN 1600214045 (http://www.vanstockum.nl/product/7188809/Methods-In-Protein-Structure-And-Stability-Analysis.html) (18 pp)
Wang, B., Martin, S.R, Newman, R.A., Hamilton, S.L., Shea, M.A., Bayley, P.M., and Beckingham, K. (2004) Biochemical properties of V91G calmodulin: A calmodulin point mutation that deregulates muscle contraction in Drosophila. Protein Science 13 3285-3297 (http://dx.doi.org/10.1110/ps.04928204) (13 pp)
Hines, R., Sorensen, B.R., Shea, M.A., Maury, W. (2004) PU.1 Binding to ets Motifs within the Equine Infectious Anemia Virus Long Terminal Repeat (LTR) Enhancer: Regulation of LTR Activity and Virus Replication in Macrophages J. Virology 78: 3407–3418. (http://dx.doi.org/10.1128/JVI.78.7.3407-3418.2004) (12 pp)
Akyol, Z., Bartos, J., Jaren, O.R., Faga, L., Shea, M.A. and Hell, J. (2004) Apo-Calmodulin Binds with its COOH-terminal Domain to the N-methyl-D-aspartate Receptor NR1 C0 Region J. Biol. Chem. 279(3): 2166-2175. (http://dx.doi.org/10.1074/jbc.M302542200 (10 pp)
Faga, L.A., Sorensen, B.R., VanScyoc, W.S., and Shea, M.A. (2003) Basic Interdomain Boundary Residues in Calmodulin Decrease Calcium Affinity of Sites I and II by Stabilizing Helix-Helix Interactions Proteins: Structure, Function & Genetics 50: 381-391. (http://dx.doi.org/10.1002/prot.10281) (11 pp)
Leonard, A.S., Bayer, K-U, Merrill, M., Shea, M.A., Schulman, H., and Hell, J.W. (2002) Regulation of CaMKII Docking to NMDA Receptors by Calcium/Calmodulin and a-Actinin J. Biol. Chem. 277: 48441-48448 (http://dx.doi.org/10.1074/jbc.M205164200) (8 pp)
Jaren, O.R., Kranz, J.K., Sorensen, B.R., Wand, A.J., Shea, M.A. (2002) Calcium-Induced Conformational Switching of Paramecium Calmodulin: Changes in the Protein Backbone Observed by Heteronuclear NMR Studies. Biochemistry 41: 14158-14166. (http://dx.doi.org/10.1021/bi026340+) (9 pp)
VanScyoc, W.S., Sorensen, B.R., Rusinova, E., Laws, W., Ross, J.B.A., and Shea, M.A. (2002) Domain-Specific Fluorescence of Calmodulin: Phenylalanine Reports Exclusively on Calcium Binding to the N-Domain Biophysical Journal 83: 2767-2790. (http://dx.doi.org/10.1529/biophysj.102 (24 pp)
Xiong, L-W, Newman, R.A., Rodney, G.C., Thomas, O., Zhang, J-Z, Persechini, A., Shea, M.A., and Hamilton, S.L. (2002) Lobe Dependent Regulation of Ryanodine Receptor Type One by Calmodulin J. Biol. Chem. 277:40862–40870. (http://dx.doi.org/10.1074/jbc.M206763200) (9 pp)
Sorensen, B.R., Faga, L.A., Hultman, R., Shea, M.A. (2002) Interdomain Linker Increases Thermostability and Decreases Calcium Affinity of Calmodulin N-Domain. Biochemistry 41: 15-20. (http://dx.doi.org/10.1021/bi011718+) (6 pp)
Sun, H., Yin, D., Coffeen, L.A., Shea, M.A., and Squier, T.C. (2001) Mutation of Tyr138 Disrupts the Structural Coupling Between the Opposing Domains in Vertebrate Calmodulin. Biochemistry 40:9605-9617. (http://dx.doi.org/10.1021/bi0104266) (13 pp)
VanScyoc, W. and Shea, M.A. (2001) Phenylalanine fluorescence studies of calcium binding to N-domain fragments of Paramecium calmodulin mutants show increased calcium affinity correlates with increased disorder. Protein Science 10:1758-1768. (http://dx.doi.org/10.1110/ps.11601) (11 pp)
Sorensen, B.R., Eppel, J.T., Shea, and M.A. (2001) Paramecium Calmodulin Mutants Defective in Ion Channel Regulation Associate with Melittin in the Absence of Calcium but Require it for Tertiary Collapse. Biochemistry 40:896-903. (http://dx.doi.org/10.1021/bi0023091) (8 pp)

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