University of Iowa
Department of Biochemistry
4-403 BSB
Iowa City, IA 52242-1109 USA phone: 877-846-8569
or 319-335-7932
fax: (319) 335-9570
biochem@uiowa.edu

Department of Biochemistry

Recent Publications :: David Price

Jeronimo, C., Forget, D., Bouchard, A., Li, Q., Chua, G., Poitras, C., Thérien, C., Bergeron, D., Bourassa, S., Greenblatt, J., Chabot, B., Poirier, G.G., Hughes, T.R., Blanchette, M., Price, D.H. and Coulombe, B. (2007) Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Molecular Cell, 27:262-74.
Biglione, S., Byers, S.A., Price, J.P., Nguyen, V.T., Bensaude, O., Price, D.H., and Maury, W.J. (2007) Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, Seliciclib and Flavopiridol correlates with release of free P-TEFb from the large form of the complex. Retrovirology, 4:47.
Sedore, S.C., Byers, S.A., Biglione, S., Maury, W.J., and Price, D.H. (2007) Manipulation of P-TEFb control machinery by HIV: Recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR. Nuc. Acids. Res. 35:4347-58.
Cheng, B. and Price, D.H. (2007) Properties of RNA polymerase II elongation complexes before and after the P-TEFb-mediated transition into productive elongation. J. Biol. Chem. 282:21901-12.
Li, Q., Cooper, J.J., Altwerger, G.H., Feldkamp, M.D., Shea, M.A., and Price, D.H. (2007) HEXIM1 is a promiscuous double-stranded RNA binding protein and interacts with RNAs in addition to 7SK in cultured cells. Nuc. Acids. Res. 25:2503-2512.
Peterlin, B.M., and Price, D.H. (2006) Controlling the elongation phase of transcription with P-TEFb. Mol. Cell. 23:297-305.
Barboric, M., Kohoutek, J., Price, J.P., Blazek, D., Price, D.H., Peterlin, B.M. (2005) Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb. EMBO J. 24:4291-4303.
Palangant, M., Renner, D.B., Price, D.H., and Landick, R., (2005) A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS. Proc. Natl. Acad. Sci. 102:15036-15041.
Adamson, T.E., Shutt, D.C., and Price, D.H. (2005) Functional coupling of cleavage and polyadenylation with transcription of mRNA. J. Biol. Chem. 280:32262-32271.
Byers, S.A., Schafer, B., Sappal, D.S., Brown, J., and Price, D.H. (2005) The antiproliferative agent MLN944 preferentially inhibits transcription. Mol Cancer Ther. 4:1260-1267.
Li., Q., Price, J.P., Byers, S.A., Cheng, D., Peng, J., and Price, D.H. (2005) Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186. J. Biol. Chem. 280:28819-28826.
Byers, S.A., Price, J.P., Cooper, J.J., Li, Q, and Price, D.H. (2005) HEXIM2, a HEXIM1 related protein regulates positive transcription elongation factor b through association with 7SK. J. Biol. Chem. 280:16360-16367.
Shore, S.M., Byers, S.A., Dent, P., and Price, D.H. (2005) Characterization of Cdk955 and differential regulation of two Cdk9 isoforms. Gene 350:51-58.
Jiang, Y. and Price, D.H. (2004) Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector. Cell Cycle 23:1151-1153.
Michels, A.A., Fraldi, A., Li, Q, Adamson, T.E., Bonnet, F, Nguyen, V.T., Sedore, S.C., Price J.P., Price, D.H., Lania, L., and Bensaude, O. (2004) Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclinT) inhibitor. EMBO Journal 23:2608-2619.
Jiang, Y., Liu, M., Spencer, C.A., and Price, D.H. (2004) Involvement of transcription termination factor 2 in mitotic repression of transcription elongation. Mol. Cell 14: 375-385.
Price, D.H. (2004) Gene expression in eukaryotes: RNA polymerase II elongation control. Encyclopedia of Biological Chemistry, Academic Press/Elsevier Science 3:766-769.
Adamson, T.E., Shore, S.M., and Price, D.H. (2003) Analysis of RNA polymerase II elongation in vitro. Methods in Enzymology 371: 264-275.
Adamson, T.E. and Price, D.H. (2003) Co-translational processing of histone mRNAs. Mol. Cell. Biol. 23: 4046-4055.
Shore, S.M., Byers, A.B., Maury, W., and Price, D.H. (2003) Identification of a novel isoform of Cdk9. Gene 301: 175-182.
Moteki, S. and Price, D.H. (2002) Functional coupling of capping and transcription of mRNA. Molecular Cell 10: 599-609.
Renner, D.B., Yamaguchi, Y., Wada, T., Handa, H., and Price, D.H. (2001) A highly purified RNA polymerase II elongation control system. J. Biol. Chem. 276: 42601-42609.
Zhou, M., Nekhai, S., Bharucha, D.C., Kumar, A., Ge, H., Price, D.H., Egly, J.M., and Brady, J.N. (2001) TFIIH inhibits CDK9 phosphorylation during human iummunodeficiency virus Type 1 transcription. J. Biol. Chem. 276: 44633-44640.
Chao, S-H., Price, D.H. (2001) Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo. J. Biol. Chem. 276: 31793-31799.
Chao, S-H., Greenleaf, A.L., Price, D.H. (2001) Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription. Nucleic Acids Res. 29: 767-773.

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