University of Iowa
Department of Biochemistry
4-403 BSB
Iowa City, IA 52242-1109 USA phone: 877-846-8569
or 319-335-7932
fax: (319) 335-9570
biochem@uiowa.edu

Department of Biochemistry

Recent Publications :: Rama Mallampalli

Henderson, F.C., Miakotina, O.L., and Mallampalli, R.K. (2006) Proapoptotic effects of P. aeruginosa involve inhibition of surfactant phosphatidylcholine synthesis. J. Lipid Res. 47:2314-2324.
McCoy, D., Fisher, K., Robichaud, J., Ryan, A.J., and Mallampalli, R.K. (2006) Transcriptional regulation of lung cytidylyltransferase in developing transgenic mice. Am. J. Respir. Cell Mol. Biol. 35:394-402.
Zhou, J., Wu, Y., Henderson, F., McCoy, D.M., Salome, R.G., McGowan, S.E., and Mallampalli, R.K. (2006) Adenoviral gene transfer of a mutant surfactant enzyme aameliorates pseudomonas-induced lung injury. Gene Ther. 13:974-85.
Ryan, A.J., Andrews M., Zhang L., Zhou J., and Mallampalli, R.K.. (2006) c-Jun N-terminal kinase regulates CTP:phosphocholine cytidylyltransferase. Arch. Biochem. Biophys. 447:23-33.
Sinn, P.L., Penisten, A.K., Burnight, E.R., Hickey, M.A., Williams, G., McCoy, D.M., Mallampalli, R.K., and McCray, P.B. (2005) Gene transfer to respiratory epithelia with lentivirus pseudotyped with Jaagsiekte sheep retrovirus envelope glycoprotein. Hum. Gene Ther. 16:479-488.
Agassandian, M., Zhou, R., Tephly, L.A., Ryan, A.J., Carter, A.B., and Mallampalli, R.K. (2005) Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:Phosphocholine cytidylyltransferase. J. Biol. Chem. 280:21577-21587.
Xu, Z., Zhou, J., McCoy, D.M., Mallampalli, R.K. (2005) LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthsis in lung epithelia. J. Lipid Res. 46:1229-1238.
Miakotina, O.L., Agassandian, M., Shi, L., Look, D.C. Mallampalli, R.K., (2005) Adenovirus stimulates choline efflux by increasing expression of organic cation transporter-2. Am. J. Physiol. Lung Cell. Mol. Physiol. 288:L93-L102.
Monick, M.M., Mallampalli, R.K., Bradford, M., McCoy, D., Gross, T.J., Flaherty, D.M., Powers, L.S., Cameron, K., Selly, S., Merrill, Jr., A.H., and Hunninghake, G.W. (2004) Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity. J. of Immunol. 173:123-135.
Monick, M.M., Cameron, K., Powers, L.S., Butler, N.S., McCoy, D., Mallampalli, R.K., and Hunninghake, G.W. (2004) Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus. Am. J. Respir. Cell Mol. Biol. 30:844-852.
Zhou J., You, Y., Ryan, A.J., and Mallampalli, R.K. (2004) Up-regulation of surfactant synthesis triggers ABCA1-mediated basolateral phospholipid efflux. J. Lipid Res. 45:1758-1767.
Agassandian, M., Mathur S.N., Zhou J., Field F.J., and Mallampalli R.K. (2004) Oxysterols trigger ABCA1-mediated basolateral surfactant efflux. Am. J. Respir. Cell Mol. Biol. 31:227-233.
Ryan, A.J., Fisher K., Thomas, C.P., and Mallampalli, R.K. (2004) Transcriptional repression of the CTP:phosphocholine cytidylyltransferase gene by sphingosine. Biochem. J. 382:741-750.
Zhou J., You Y, Zabner J, Ryan A.J., and Mallampalli, R.K. (2004) The CCT promoter directs high-level transgene expression in distal lung epithelial cell lines. Am J. Resp. Cell Mol. Biol. 30:61-68.
Zhou, J., Ryan, A.J., Medh, J., and Mallampalli, R.K. (2003) Oxidized lipoproteins inhibit surfactant phosphatidylcholine synthesis via calpain-mediated cleavage of CPT:Phosphocholine cytidylyltransferase. J. Biol. Chem. 278: 37032-37040.
Ryan, A.J., McCoy, D.M., McGowan, S.E., Salome, R.G., and Mallampalli, R.K. (2003) Alveolar sphingolipids generated in response to TNFa modifies surfactant biophysical activity. J. Appl. Physiol. 94: 253-258.
Mallampalli, R.K., Ryan, A.J. Carroll, J.L., Salome, R.G., McCoy, D.M., and Thomas, C.P. (2002) Lipid deprivation increases surfactant phosphatidylcholine synthesis via a sterol-sensitive regulatory element within the CTP:phosphocholine cytidylyltransferase promoter. Biochem. J. 362: 81-88.
Ryan, A.J., Medh, J.D., McCoy, D.M., Salome, R.G., and Mallampalli, R.K (3) (2002) Maternal loading with very low-density lipoproteins stimulates fetal surfactant synthesis. Am J. Physiol. 283: L310-L318.
Carroll, Jr., J.L., McCoy, D.M., McGowan, S.E., Salome, R.G., and Mallampalli, R.K. (2002) Pulmonary specific expression of tumor necrosis factor-a alters surfactant lipid metabolism. Am. J. Physiol. 282: L735-L742.

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