University of Iowa
Department of Biochemistry
4-403 BSB
Iowa City, IA 52242-1109 USA phone: 877-846-8569
or 319-335-7932
fax: (319) 335-9570
biochem@uiowa.edu

Department of Biochemistry

Recent Publications :: Pamela K. Geyer

Kuhn-Parnell E, Helou C, Marion D, Gilmore B, Parnell T, Wold M, Geyer P. Investigation of the properties of non-gypsy Su(Hw) binding sites. Genetics. 2008 Jun 18 [Epub ahead of print]
Parnell, T.J., Kuhn, E.J., Gilmore, B.L., Helou, C., Wold, M.S. and Geyer, P.K. (2006) Identification of genomic sites that bind the Drosophila Suppressor of Hairy-wing protein. Mol. Cell. Biol. 26:5983-5993.
Wallrath, L.L., and Geyer, P.K. (2006) TFIIIC in the genome. Cell 125:829-831.
Drapeau, M.D., Cyran, S.A., Viering, M.M., Geyer, P.J., and Long, A.D. (2006) A cis-regulatory sequence within the yellow locus of Drosophila melanogaster required for normal male mating success. Genetics 172:1009-1030.
Li, X.-G., and Geyer, P.K. (2005) Gene Silencing, in Encyclopeida of Science and Technology, in press.
Schulze, S.R., Curio-Penny, B., Li, Y., Imani, R.A., Rydberg, L., Geyer, P.K., and Wallrath, L.F. (2005) Molecular genetic analysis of the nested Drosophila melanogaster Lamin C gene. Genetics 171:185-196.
Wallrath, L.L., Danzer, J.R., Yazgan, O. and P.K. Geyer (2004) Nuclear organization, chromatin structure and gene silencing, In Encyclopedia of Biological Chemistry (W.J. Lennarz & M.D. Lane, eds), Elsevier, Oxford, Vol 3: pp. 105-108.
Kuhn, E.J., Hart, C.M., and Geyer, P.K. (2004) Studies of the role of the Drosophila scs and scs' insulators in defining boundaries of a chromosome puff. Mol. Cell. Biol. 24(4):1470-1480.
Parnell, T.J., Grade, S.K., Geyer, P.K. and Wallrath, L.L. (2003) Position-effect variegation in human genetic disease, in Cooper D (Ed.), Encyclopedia of the Human Genome. John Wiley & Sons, Ltd, p. 642-646 (Volume 4).
Parnell, T.J., Viering, M.M., Skjesol, A., Helou, C., Kuhn, E.J., and Geyer, P.K. (2003) An endogenous suppressor of Hairy-wing insulator separates regulatory domains in Drosophila. Proc. Nat'l. Acad. Sci. 100:13436-13441.
Kuhn, E.J. and Geyer, P.K. (2003) Genomic insulators: connecting properties to mechanism. Curr. Opin. in Cell Biol. 15:259-265.
Kuhn, E.J., Viering, M.M., Rhodes, K.M. and Geyer, P.K. (2003) A test of insulator interactions in Drosophila. EMBO J. 22:2463-2471.
Chen, J.-L., Huisinga, K.L., Viering, M.M., Ou, Sharon, Wu, C.-T., and Geyer, P.K. (2002) Enhancer action in trans is permitted throughout the Drosophila genome. Proc. Natl. Acad. Sci. 99:3723-3728.

Figure Legend. Two gypsy insulator proteins, Suppressor of Hairy-wing and Modifier67.2, co-localize at hundreds of sites within the polytene chromosomes that do not contain insertions of the gypsy retrovirus. These data suggest that these gypsy insulator proteins contribute to a global organization of transcriptional domains. Understanding the mechanism of action of these proteins will shed lights on transcriptional regulatory processes in the Drosophila genome.

Also see PubMed for recent publications.