Professor, Division of Infectious Diseases, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242 USA

and

Staff Physician, Department of Veterans Affairs Medical Center, Iowa City,Iowa 52240 USA

To contact Dr. Kirchhoff,   louis-kirchhoff@uiowa.edu

Learn More about Dr. Kirchhoff's work on Chagas Disease 

Find out why Dr. Kirchhoff goes to Mexico so much.

Mailing address: 4-403 BSB    University of Iowa    Iowa City, Iowa     52242 USA

EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, and honors.  Include present membership on any Federal Government public advisory committee. List, in chronological order, the titles, all authors, and complete references to all publications during the past three years and to representative earlier publications pertinent to this application. If the list of publications in the last three years exceeds two pages, select the most pertinent publications. DO NOT EXCEED TWO PAGES.

Previous Employment

1980-81                Fellow, Infectious Diseases/Geographic Medicine, University of Virginia, Charlottesville, VA

1981-85                Medical Staff Fellow, Laboratories of Clinical Investigation and Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD

1985-1990               Assistant Professor, Department of Internal Medicine, Infectious Diseases, Univ. of Iowa, Iowa City, IA

1990-1997                Associate Professor, Department of Internal Medicine, Infectious Diseases, Univ. of Iowa, Iowa City, IA

1997-present                Professor, Department of Internal Medicine, Infectious Diseases, Univ. of Iowa, Iowa City, IA

1985-present                Medical Staff Physician, Department of Veterans Affairs Medical Center, Iowa City, IA

1997-present               President, Goldfinch Diagnostics Inc., Iowa City, IA

Honors

1975               Yale International Student Fellowship

1976               NCI Pre-doctoral Summer Fellowship (Yale)

1977               Harold Lamport Biomedical Research Prize (Yale)

1980               University of Michigan Internal Medicine House Officer Research Award

1986               Syntex Scholars Award

1990                            Established Investigatorship, American Heart Association

1998                              National Blood Foundation Scholar

Bibliography

Selected Publications in Journals

 1.        Engman DM, Reddy LV, Donelson JE, Kirchhoff LV. Trypanosoma cruzi exhibits inter‑ and intra‑strain heterogeneity in molecular karyotype and chromosomal gene location. Mol Biochem Parasitol 1987;22:115-123.

 2.            Kirchhoff LV, Kim KS, Engman DM, Donelson JE. Ubiquitin genes in Trypanosomatidae. J Biol Chem 1988;263:12698‑12704.

 3.            Moser DR, Kirchhoff LV, Donelson JE. Detection of Trypanosoma cruzi by polymerase chain reaction gene amplification. J Clin Microbiol 1989;27:1744‑1749.

 4.            Hoft DF, Kim KS, Otsu K, Moser DR, Yost WJ, Blumin JH, Donelson JE, Kirchhoff LV. Trypanosoma cruzi expresses diverse repetitive protein antigens. Infect Immun 1989;57:1959‑1967.

 5.            Kirchhoff LV, Hoft DF. Immunization and challenge of mice with insect‑derived metacyclic trypomastigotes of Trypanosoma cruzi. Parasite Immunol 1990;12:65‑74.

 6.            Kerndt PR, Waskin HA, Kirchhoff LV, Steurer F, Waterman SH, Nelson J, Gellert GA, Shulman IA. Prevalence of antibody to Trypanosoma cruzi among blood donors in Los Angeles, California. Transfusion 1991;31:814‑818.

 7.            Appleman MD, Shulman IA, Saxena S, Kirchhoff LV. Use of a questionnaire to identify potential blood donors at risk for infection with Trypanosoma cruzi. Transfusion 1993;33:61‑64.

 8.        Otsu K, Donelson JE, Kirchhoff LV. Interruption of a Trypanosoma cruzi gene encoding a protein containing 14‑amino acid repeats by targeted insertion of the neomycin phosphotransferase gene. Mol Biochem Parasitol 1993;57:317‑330.

 9.            Kirchhoff LV. American trypanosomiasis (Chagas disease): A tropical disease now in the United States. N Engl J Med 1993;329:639‑644.   

10.            Hoft DF, Lynch RG, Kirchhoff LV. Kinetic analysis of antigen specific immune responses in resistant and susceptible mice during infection with Trypanosoma cruzi. J Immunol 1993;151:7038‑7047.

11.            Kim KS, Teixeira SMR, Kirchhoff LV, Donelson JE. Transcription and editing of cytochrome oxidase II RNAs in Trypanosoma cruzi. J Biol Chem 1994;269:1206‑1211.

12.            Teixeira SMR, Russell DG, Kirchhoff LV, Donelson JE. A differentially expressed gene family encoding "amastin," a glycoprotein of Trypanosoma cruzi amastigotes. J Biol Chem 1994;269:20509‑20516.

13.            Engman DM, Henkle KJ, Kirchhoff LV, Donelson JE. Processing of Trypanosoma cruzi hsp70 pre‑mRNA is sensitive to heat shock. Exp Parasitol 1995;80:575-577.

14.            Barr SC, Van Beek O, Carlisle-Nowak MS, Lopez JW, Kirchhoff LV, Zajac A, de Lahunta A. Trypanosoma cruzi infection in Walker hounds in Virginia. Am J Vet Res 1995;56:1037‑1044.

15.            Teixeira SMR, Kirchhoff LV, Donelson JE. Post‑transcriptional elements regulating expression of mRNAs from the amastin/tuzin gene cluster of Trypanosoma cruzi. J  Biol Chem 1995;270:22586-22594.

16.       Otsu K, Donelson JE, Kirchhoff LV. Interruption of both alleles of a Trypanosoma cruzi gene encoding a protein containing 14‑amino acid repeats by targeted insertion of NEO^r and HYG^r. Exp Parasitol 1995;81:529-535.

17.            Ochs DE, Hnilica VS, Moser DR, Smith JH, Kirchhoff LV. Postmortem diagnosis of autochthonous acute Chagasic myocarditis by PCR amplification of a species‑specific DNA sequence of Trypanosoma cruzi. Am J Trop Med Hyg 1996;34:526‑529.

18.            Kirchhoff LV, Ochs DE, Votava JR, Moser DE. Comparison of polymerase chain reaction and microscopic methods for detecting Trypanosoma cruzi. J Clin Microbiol 1996;34:1171‑1175.

19.            Ochs DE, Otsu K, Moser DR, Kirchhoff LV. Maxicircle Genomic Organization and Editing of ATPase Subunit 6 Transcripts in Trypanosoma cruzi. Mol Biochem Parasitol 1996;76:267‑278.

20.            Shikanai‑Yasuda MA, Ochs DE, Tolezano JE, Kirchhoff LV.  Use of PCR for detecting Trypanosoma cruzi in reduviid bugs fed on patients with chronic Chagas’ disease. Trans R Soc Trop Med Hyg 1996;90:649‑651.

21.            Leiby DA, Read EJ, Benes BA, Yund AJ, Stumpf RJ, Kirchhoff LV, Dodd RY. Seroepidemiology of Trypanosoma cruzi, etiologic agent of Chagas’ disease, in US blood donors. J Infect Dis 1997;176:1047-1052.

22.            Kirchhoff LV. Use of a PCR assay for diagnosing African sleeping sickness. Central African J Med 1998;44:134‑136.

23.            Teixeira SMR, Otsu K, Hill KL, Kirchhoff LV, Donelson JE. Expression of a marker for intracellular Trypanosoma cruzi amastigotes in extracellular spheromastigotes. Mol Biochem Parasitol 1999;98:265‑270.

24.            Catmull J, Wilson ME, Kirchhoff LV, Metwali A, Donelson JE. Induction of specific cell-mediated immunity in mice by oral immunization with Salmonella expressing Onchocerca volvulus glutathione S‑transferase. Vaccine 1999;17:31-39.

25.            Teixeira SMR, Kirchhoff LV, Donelson JE. Trypanosoma cruzi: Suppression of tuzin gene expression by its 5’‑UTR and spliced leader addition site. Exp Parasitol 1999;93:143‑151.

26.            Enemark H, Seibaek MB, Kirchhoff LV, Jensen GB. Kronisk Chagas sygdom – et ekko fra ungdommen [Chronic Chagas disease – an echo from the past]. Ugeskrift for Laeger [Danish Medical Bulletin] 2000;162:2567‑2569.

27.            Coughlin BC, Teixeira SM, Kirchhoff LV, Donelson JE. Amastin mRNA abundance in Trypanosoma cruzi is controlled by a 3’ untranslated region position dependent cis‑element and an untranslated region binding protein. J Biol Chem 2000;275:12051‑12060.

28.            Grandgenett PM, Coughlin BC, Kirchhoff LV, Donelson JE. Differential expression of GP63 genes in Trypanosoma cruzi. Mol Biochem Parasitol 2000 (In press).

29.            Bradley KK, Bergman DK, Woods PJ, Crutcher JM, Kirchhoff LV. American trypanosomiasis (Chagas disease) in dogs in Oklahoma. J Am Vet Med Assoc 2000 (In press).

30.            Leiby DA, Rentas FJ, Nelson KE, Stambolis VA, Ness PM, Parniss C, McAllister Jr H, Yawn DH, Stumpf RJ, Kirchhoff LV. Evidence of Trypanosoma cruzi infection (Chagas’ disease) among patients undergoing cardiac surgery. Circulation 2000 (In press).

Recent Book Chapters

 1.            Kirchhoff LV. Trypanosoma species (American trypanosomiasis, Chagas disease): Biology of trypanosomes, In: Mandell GL, Bennett JE, Dolin R, eds: Principles and Practice of Infectious Diseases, 5^th ed, New York, Churchill Livingstone, 2000;2845‑2853.

2.              Kirchhoff LV. Trypanosomiasis, In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, eds: Harrison’s Principles of Internal Medicine, 15^th ed, New York, McGraw‑Hill, 2000;1193‑1196.

3.              Kirchhoff LV. Agents of African trypanosomiasis (sleeping sickness), In: Mandell GL, Bennett JE, Dolin R, eds: Principles and Practice of Infectious Diseases, 5^th ed, New York, Churchill Livingstone, 2000;2853‑2858.

4.              Kirchhoff LV. American trypanosomiasis (Chagas' disease), In: Rakel RE, ed: Conn's Current Therapy 2000, 52^nd ed, New York, W.B. Saunders, 2000;101‑102.

5.              Tanowitz HB, Wittner M, Werner C, Bacchi C, Kirchhoff LV. Trypanosomiasis, In: Lederberg J, Alexander M, Bloom BR, Hopwood D, Hull R, Iglewski BH, Laskin AI, Oliver SG, Schaechter M, Summers WC, eds: Encyclopedia of Microbiology, New York, Academic Press, Inc. 2000 (In press).

6.              Kirchhoff LV. American trypanosomiasis (Chagas disease), In: Gillespie SH, Pearson RD, eds: Principles and Practice of Clinical Parasitology, Oxford, Oxford University Press, 2000: (In press).

7.              Kirchhoff LV. Trypanosoma cruzi (American trypanosomiasis, Chagas disease), In: Yu V, ed: Antimicrobial Therapy and Vaccines, New York, Lippincott Williams and Wilkins, 2000: (In press).

8.              Kirchhoff LV, Bacchi CJ, Wittner M, Tanowitz HB. African trypanosomiasis (sleeping sickness), In: Tice A, Griffiths JK, eds: Current Opinion in Infectious Diseases, Philadelphia, Current Science, 2000;66‑69.

9.              Kirchhoff LV, Bacchi CJ, Wittner M, Tanowitz HB. American trypanosomiasis (Chagas disease), In: Tice A, Griffiths JK, eds: Current Treatment Options in Infectious Diseases, Current Science, Philadelphia, 2000;59‑65.

10.           Kirchhoff LV. Nifurtimox, In: Yu V, ed: Antimicrobial Therapy and Vaccines, New York, Lippincott Williams and Wilkins, 2000: (In press).

11.           Kirchhoff LV. Benznidazole, In: Yu V, ed: Antimicrobial Therapy and Vaccines, New York, Lippincott Williams and Wilkins, 2000: (In press).